I watch my neighbour Margaret every morning from my kitchen window. She's 73, and almost every morning at around 7.30, she emerges from her front door in her bright purple trainers. Not for a jog, nothing so dramatic. She simply walks. Around the block, through the park, stopping to chat with other early risers. Forty-five minutes later, she's back, slightly breathless but clearly energised.

What most of us don't fully grasp is that during those 45 minutes, something extraordinary is happening inside her body. Her cells are literally transforming themselves, her mitochondria are multiplying, her muscles are releasing chemical messengers that will influence her metabolism for the next two days. She's not just burning calories. She's rewriting her cellular future. This is the story I wish more people understood: movement isn't just about weight loss or looking good in summer clothes. It's about giving your body the single most powerful tool it has for staying metabolically healthy as you age.

When sitting became the enemy

"Sitting is the new smoking," they say. And whilst that might sound dramatic, the research backing this claim is rather sobering. I've spent years diving into the studies, and here's what keeps me awake at night: even if you're religious about your evening gym sessions, sitting for eight hours a day can still wreak havoc on your metabolism.

But this isn't about shaming anyone who works at a desk (myself included). It's about understanding that our bodies weren't designed for the modern world we've created. We've engineered movement out of daily life so thoroughly that we now have to consciously engineer it back in. The science is clear, though it took us decades to understand it properly. When researchers began studying the metabolic effects of exercise, they initially focused on the obvious: calories in, calories out. Rather like looking at a symphony orchestra and only listening to the drums, you miss the beautiful complexity of what's actually happening.

The cellular symphony

Let me tell you about what's really going on when you move. Last year, I had the privilege of interviewing Dr Sarah Chen, a mitochondrial researcher at Cambridge. She explained it to me like this: "Imagine your cells are like a city, and the mitochondria are the power plants. Exercise doesn't just tell the existing power plants to work harder, it literally builds new ones."

The technical term is mitochondrial biogenesis, but I prefer Sarah's analogy. When you exercise regularly, your body recognises the increased energy demand and responds by constructing more cellular power plants. In young adults, high-intensity interval training can increase mitochondrial capacity by 49%. In older adults? An even more impressive 69%.

Sixty-nine percent. Think about that for a moment. Your 70 yearold body can actually build more new mitochondria in response to exercise than your 20 year old body could. This isn't about trying to turn back the clock, it's about recognising that the clock keeps ticking forward in your favour when you give your body what it needs.

But there's more. Exercise also triggers something called mitophagy, essentially cellular housekeeping that removes damaged mitochondria. It's like having a renovation crew come through and strip out all the old, inefficient wiring while the construction team installs brand-new systems.

Your muscles are talking

Here's something that surprised me and might surprise you too: your muscles are chatty. Really chatty. When they contract, they release dozens of signalling molecules called myokines that have conversations with your liver, your fat tissue, even your brain.

I think of it like this: when you move, your muscles become the town criers of your body, shouting instructions to every other organ system. "Improve insulin sensitivity!" they call to your liver. "Reduce inflammation!" they tell your fat cells. "Grow new connections!" they whisper to your brain. This is why movement benefits extend far beyond the muscles you're actually using. It's why a simple walk can improve your blood sugar control for up to 48 hours afterwards. Your muscles, comprising about 40% of your body weight, are essentially your body's largest endocrine organ, and they only start talking when you make them work.

Is there a magic numbers

Now, you might be wondering: How much is enough? I get this question constantly, and the honest answer is both simpler and more nuanced than you might expect. The research suggests what I call the "metabolic minimums":

Strength training: Two to three sessions weekly. Nothing fancy, compound movements that make your large muscle groups work together. Think squats, push-ups, carrying heavy shopping bags up stairs. The key is reaching what researchers call "muscular fatigue" - that point where your muscles are genuinely challenged. I learned this lesson personally when I started working with a trainer named James. "We're not trying to build you into The Rock," he told me during our first session. "We're trying to preserve what you've got and maybe add a bit more." That perspective shift was everything. Strength training isn't about ego; it's about maintaining your metabolic machinery.

Zone 2 cardio: Two to three hours weekly of moderate-intensity exercise. This is the intensity where you can still hold a conversation, but you're definitely breathing harder than normal. For me, it's a brisk walk with my dog, Bella, where I can still answer her enquiring looks about whether we're heading to the good park, but I'm definitely working.

High-intensity intervals: Once or twice weekly. Short bursts of high-intensity effort with recovery periods. The beauty of HIIT is its efficiency, 15 to 20 minutes can create metabolic adaptations that take hours of moderate exercise to achieve.

Daily movement: Seven to ten thousand steps, preferably distributed throughout the day rather than crammed into one session.

Sedentary breaks: This might be the most important one. Every 30 to 60 minutes, interrupt your sitting with even brief movement. I set a timer on my phone, it's annoying, but it works.

Do you have to enjoy it? Yes, you do!

Here's what all the research papers miss, but what every successful exerciser knows: you have to enjoy it. Or at least not actively hate it. I spent years forcing myself through workouts I despised, wondering why I couldn't stick to any routine. Then I discovered something revolutionary: walking whilst listening to podcasts. Suddenly, my "exercise time" became my "learning time," and everything changed.

The research backs this up. Studies show that enjoyment is the strongest predictor of long-term exercise adherence, more important than perceived health benefits or even fitness level. This makes perfect sense when you think about it. We don't stick to things that make us miserable, no matter how good they supposedly are for us.

The Beautiful Truth

Perhaps you're reading this thinking, This all sounds lovely, but I haven't exercised in years. That's perfectly fine. In fact, you're in an enviable position, every small improvement will create disproportionate benefits. Research shows that the steepest part of the health-benefit curve comes right at the beginning. Going from completely sedentary to just 10 minutes of daily walking reduces mortality risk by 15%. Each additional 10 minutes provides further benefit, but those first steps literally offer the biggest bang for your buck.

What I find most hopeful about all this research is that our bodies remain remarkably responsive to movement throughout life. Those mitochondrial adaptations I mentioned? They occur even in advanced age. Your muscles can still grow stronger in your seventies and eighties. Your cardiovascular system can still improve its efficiency.

This isn't about trying to recapture your youth or compete with twenty-somethings at the gym. It's about recognising that the conversation between movement and metabolism never stops, and you get to choose what your body hears.

Every morning when I see Margaret in her purple trainers, I'm reminded that she's not just walking around the block. She's actively participating in her own cellular wellbeing. She's telling her mitochondria to multiply, instructing her muscles to release their beneficial signals, teaching her body to handle glucose more efficiently.

And the beautiful thing? It's never too late to join that conversation. Your body is listening, ready to respond, waiting for you to give it the signal that you're ready to thrive.

The power to influence your metabolic health is quite literally in your hands, or rather, in your feet. One step at a time.

Stay young and healthy!

The information presented here is intended solely for educational purposes. While we strive to provide accurate, evidence-based content, this is not medical advice and should never replace consultation with healthcare professionals. Science evolves constantly, and individual health circumstances vary widely. Please consult qualified healthcare professionals for specific health concerns, diagnosis, or treatment recommendations.

Vera Hartwell

‘Bridging the gap between lab coats and living rooms'

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